MYASTHENIA GRAVIS OCCURRING IN AN INFANT BORN OF A MYASTHENIC MOTHER

作者：Fred L. Strickroot · 发表于：JAMA · 年份：1942 · DOI：10.1001/jama.1942.82830500001010 · 被引用次数：56 · 研究领域：Myasthenia Gravis and Thymoma、Pituitary Gland Disorders and Treatments、Parkinson's Disease and Spinal Disorders

Up until the time that it was discovered that symptoms of myasthenia gravis were ameliorated by the administration of a parasympatheticomimetic drug, the number of cases of this disease reported was small. Although physostigmine definitely benefited patients with this neuromuscular disorder, its side effects were so undesirable that they precluded adequate treatment. Not until 1935, when Dr. Mary Walker1of Greenwich, England, first used prostigmine methylsulfate on a myasthenic patient, was there a suitable drug found to treat the condition. Although the number of such patients who have since been observed is rapidly increasing, owing in part to a suitable diagnostic test,2only a few patients who became pregnant have been carefully observed. Viets, Schwab and Brazier3have recently reviewed the literature on this subject and state that pregnancy has a favorable effect on the course of the disease, often amounting to a definite remission. In discussing