Isolation and Transmission of Human Retrovirus (Human T-Cell Leukemia Virus)

作者：M Popovic, P. S. Sarin, M. Robert-Gurroff, V. S. Kalyanaraman, David G. Mann, J Minowada, Rosella Gallo · 发表于：Science · 年份：1983 · DOI：10.1126/science.6600519 · 被引用次数：560 · 研究领域：T-cell and Retrovirus Studies、Animal Disease Management and Epidemiology、Vector-Borne Animal Diseases

Nine new isolates of human T-cell leukemia-lymphoma virus (HTLV) were obtained from cells of seven patients with malignancies of mature T cells and from two clinically normal relatives of a T-cell leukemia patient. These people were from the United States, Israel, the West Indies, and Japan. The virus was detected in the fresh T cells and was isolated from the established T-cell lines. Each isolate is closely related to the first HTLV isolate, and all the new HTLV isolates were transmitted into normal human T cells obtained from the umbilical cord blood of newborns.