THE PROLIFERATIVE STATUS OF INTESTINAL EPITHELIAL CLONOGENIC CELLS: SENSITIVITY TO S PHASE SPECIFIC CYTOTOXI CAGENTS

作者：T. A. Boarder, N. M. Blackett · 发表于：Cell Proliferation · 年份：1976 · DOI：10.1111/j.1365-2184.1976.tb01308.x · 被引用次数：32 · 研究领域：Plant Genetic and Mutation Studies

High concentrations of tritiated thymidine and cytosine arabinoside (Ara-C) have been used to selectively kill cells in the crypts of Lieberkuhn that are synthesizing DNA. The effect of these agents on the number of regenerating microcolonies seen 3 1/2 days after a range of radiation doses indicates that a majority of the clonogenic cells are proliferating rapidly and that the slowly proliferating cells at the base of the crypt do not represent the whole clonogenic population.