THE RELATIONSHIP OF SERUM GAMMA-GLOBULIN CONCENTRATION TO MALARIA AND SICKLING

作者：J. C. Edozien, A. Eyimofe Boyo, D. C. Morley · 发表于：Journal of Clinical Pathology · 年份：1960 · DOI：10.1136/jcp.13.2.118 · 被引用次数：40 · 研究领域：Hemoglobinopathies and Related Disorders、Liver Disease Diagnosis and Treatment、Hepatitis B Virus Studies

The serum protein patterns of groups of Nigerians including 98 children partially protected by "daraprim" against malaria, and 113 unprotected children, have been studied. The protected children have a significantly lower concentration of serum gamma globulin than the unprotected children from the age of 12 months onwards. In children, sicklers have a significantly higher serum gamma globulin than non-sicklers. It is suggested that sickling protects against malaria by enhancing the antibody response against the malaria parasite.