Vitamin D Receptor Fok1 Polymorphisms Affect Calcium Absorption, Kinetics, and Bone Mineralization Rates During Puberty

作者：Steven A. Abrams, Ian J. Griffin, Keli M. Hawthorne, Zhensheng Chen, Sheila Gunn, Margaret D. Wilde, Gretchen Darlington, Roman J. Shypailo, Kenneth J. Ellis · 发表于：Journal of Bone and Mineral Research · 年份：2005 · DOI：10.1359/jbmr.050114 · 被引用次数：127 · 研究领域：Vitamin D Research Studies、Bone health and osteoporosis research、Alkaline Phosphatase Research Studies

UNLABELLED: Few studies of the VDR polymorphisms have looked at calcium metabolism or long-term effects. We measured bone mineralization and calcium metabolic parameters longitudinally in a group of 99 adolescents. We found a significant relationship between calcium absorption and skeletal calcium accretion and the Fok1, but not other VDR or related, genetic polymorphisms. It seems that the Fok1 polymorphism directly affects bone mineralization during pubertal growth through an effect on calcium absorption. INTRODUCTION: There are few data regarding the relationship between genetic markers for low bone mass and changes in calcium metabolism in childhood or adolescence. We sought to identify the effects of polymorphisms of the vitamin D receptor (VDR) on calcium and bone mineral metabolism in a longitudinal study of pubertal adolescents. MATERIALS AND METHODS: Adolescents (n = 99) received comprehensive stable isotope studies of calcium absorption, bone calcium kinetics, and bone mineralization. Studies were repeated 12 months later. Polymorphisms of putative genetic markers were determined and related to bone mineralization and calcium metabolic finding. Results were analyzed by ANOVA in which changes over time were determined using the initial value as a covariate. RESULTS: Polymorphisms of the Fok1 gene of the VDR were significantly related to calcium absorption (p = 0.008) and whole body BMC (p = 0.03) and BMD (p = 0.006). The Fok1 effect on whole body BMD was significant ...