Activation of human neutrophils by C3a and C5A Comparison of the effects on shape changes, chemotaxis, secretion, and respiratory burst

作者：Markus U. Ehrengruber, Thomas Geiser, David A. Deranleau · 发表于：FEBS Letters · 年份：1994 · DOI：10.1016/0014-5793(94)00463-3 · 被引用次数：161 · 研究领域：S100 Proteins and Annexins、Venomous Animal Envenomation and Studies、Complement system in diseases

The effects of anaphylatoxin C3a on human neutrophils were studied in comparison with C5a. Both peptides induced a transient shape change response and a respiratory burst. In both cases C3a was 50- to 100-times less potent than C5a. A marked chemotactic response with bimodal concentration dependence was obtained with C5a, but no neutrophil chemotaxis was observed with C3a. Repeated stimulation led to homologous desensitization of shape changes and respiratory burst but no cross-desensitization, indicating that the two anaphylatoxins act through separate receptors. The lack of chemotactic activity suggests that C3a is not involved in neutrophil recruitment into infected or inflamed tissues.