Immunosuppression in Vivo by a Soluble Form of the CTLA-4 T Cell Activation Molecule

作者：Peter S. Linsley, Philip M. Wallace, Jennifer Johnson, Marylou G. Gibson, JoAnne L. Greene, Jeffrey A. Ledbetter, Cherry Singh, Mark A. Tepper · 发表于：Science · 年份：1992 · DOI：10.1126/science.1496399 · 被引用次数：807 · 研究领域：T-cell and B-cell Immunology、Immune Cell Function and Interaction、Immunotherapy and Immune Responses

In vitro, when the B7 molecule on the surface of antigen-presenting cells binds to the T cell surface molecules CD28 and CTLA-4, a costimulatory signal for T cell activation is generated. CTLA4Ig is a soluble form of the extracellular domain of CTLA-4 and binds B7 with high avidity. CTLA4Ig treatment in vivo suppressed T cell-dependent antibody responses to sheep erythrocytes or keyhole limpet hemocyanin. Large doses of CTLA4Ig suppressed responses to a second immunization. Thus, costimulation by B7 is important for humoral immune responses in vivo, and interference with costimulation may be useful for treatment of antibody-mediated autoimmune disease.