PECAM-1 (CD31) Cloning and Relation to Adhesion Molecules of the Immunoglobulin Gene Superfamily

作者：Peter J. Newman, Michael C. Berndt, Jack Gorski, Gilbert White, Suzanne Lyman, Cathy M. Paddock, William A. Müller · 发表于：Science · 年份：1990 · DOI：10.1126/science.1690453 · 被引用次数：957 · 研究领域：Cell Adhesion Molecules Research、Platelet Disorders and Treatments、Blood properties and coagulation

An antibody to a platelet integral membrane glycoprotein was found to cross-react with the previously identified CD31 myelomonocytic differentiation antigen and with hec7, an endothelial cell protein that is enriched at intercellular junctions. This antibody identified a complementary DNA clone from an endothelial cell library. The 130-kilodalton translated sequence contained six extracellular immunoglobulin (Ig)-like domains and was most similar to the cell adhesion molecule (CAM) subgroup of the Ig superfamily. This is the only known member of the CAM family on platelets. Its cell surface distribution suggests participation in cellular recognition events.