Comparison of tests for the detection of circulating filarial antigen (Og4C3-ELISA and AD12-ICT) and ultrasound in diagnosis of lymphatic filariasis in individuals with microfilariae

作者：Abraham Rocha, Cynthia Braga, Marcela Belém, Arturo Carrera, Ana Maria Aguiar-Santos, Paula Alexandra dos Santos Oliveira, Maria José Texeira, André Freire Furtado · 发表于：Memórias do Instituto Oswaldo Cruz · 年份：2009 · DOI：10.1590/s0074-02762009000400015 · 被引用次数：40 · 研究领域：Parasitic Diseases Research and Treatment、Parasites and Host Interactions、Parasite Biology and Host Interactions

Significant advances were made in the diagnosis of filariasis in the 1990s with the emergence of three new alternative tools: ultrasound and tests to detect circulating antigen using two monoclonal antibodies, Og4C3 and AD12-ICT-card. This study aimed to identify which of these methods is the most sensitive for diagnosis of infection. A total of 256 individuals, all male and carrying microfilariae (1-15,679 MF/mL), diagnosed by nocturnal venous blood samples, were tested by all three techniques. The tests for circulating filarial antigen concurred 100% and correctly identified 246/256 (96.69%) of the positive individuals, while ultrasound detected only 186/256 (73.44%). Of the circulating antigen tests, ICT-card was the most convenient method for identification of Wuchereria bancrofti carriers. It was easy to perform, practical and quick.