The Therapeutic Effects of Human Adipose-Derived Stem Cells in Alzheimer's Disease Mouse Models

作者：Keun‐A Chang, Hee Jin Kim, Yuyoung Joo, Sungji Ha, Yoo‐Hun Suh · 发表于：Neurodegenerative Diseases · 年份：2013 · DOI：10.1159/000355261 · 被引用次数：44 · 研究领域：Mesenchymal stem cell research、Neurogenesis and neuroplasticity mechanisms、Tissue Engineering and Regenerative Medicine

Alzheimer's disease (AD) is an irreversible neurodegenerative disease, still lacking proper clinical treatment. Therefore, many researchers have focused on the possibility of therapeutic use of stem cells for AD. Adipose-derived stem cells (ASCs), mesenchymal stem cells (MSCs) isolated from adipose tissue, are well known for their pluripotency and their ability to differentiate into multiple tissue types and have immune modulatory properties similar to those of MSCs from other origins. Because of their biological properties, ASCs can be considered for cell therapy and neuroregeneration. Our recent results clearly showed the therapeutic potential of these cells after transplantation into Tg2576 mice (an AD mouse model). Intravenously or intracerebrally transplanted human ASCs (hASCs) greatly improved the memory impairment and the neuropathology, suggesting that hASCs have a high therapeutic potential for AD.