The Central Dogma Decentralized: New Perspectives on RNA Function and Local Translation in Neurons

作者：Christine E. Holt, Erin Margaret Schuman · 发表于：Neuron · 年份：2013 · DOI：10.1016/j.neuron.2013.10.036 · 被引用次数：552 · 研究领域：RNA Research and Splicing、RNA and protein synthesis mechanisms、RNA regulation and disease

The elaborate morphology of neurons together with the information processing that occurs in remote dendritic and axonal compartments makes the use of decentralized cell biological machines necessary. Recent years have witnessed a revolution in our understanding of signaling in neuronal compartments and the manifold functions of a variety of RNA molecules that regulate protein translation and other cellular functions. Here we discuss the view that mRNA localization and RNA-regulated and localized translation underlie many fundamental neuronal processes and highlight key issues for future experiments.