Myeloid differentiation factor 88 gene is involved in antiviral immunity in grass carp Ctenopharyngodon idella

作者：Jianguo Su, Jie Dong, Teng Huang, R. Zhang, Can Yang, Jianfu Heng · 发表于：Journal of Fish Biology · 年份：2011 · DOI：10.1111/j.1095-8649.2011.02910.x · 被引用次数：20 · 研究领域：Aquaculture disease management and microbiota、interferon and immune responses、Invertebrate Immune Response Mechanisms

A full-length MyD88 cDNA (CiMyD88) was cloned and characterized from grass carp Ctenopharyngodon idella. CiMyD88 was found to be broadly expressed and was up-regulated by grass carp reovirus (GCRV) and CiMyD88 transcripts in vitro were rapidly elevated in C. idella kidney (CIK) cells after challenge with poly(I:C). These results suggest that CiMyD88 may be involved in the antiviral immune defence in C. idella.