What if Minkowski Had Been Ageusic? An Alternative Angle on Diabetes

作者：Julie McGarry · 发表于：Science · 年份：1992 · DOI：10.1126/science.1439783 · 被引用次数：666 · 研究领域：Diet and metabolism studies、Diabetes and associated disorders、Metabolism, Diabetes, and Cancer

Despite decades of intensive investigation, the basic pathophysiological mechanisms responsible for the metabolic derangements associated with diabetes mellitus have remained elusive. Explored here is the possibility that traditional concepts in this area might have carried the wrong emphasis. It is suggested that the phenomena of insulin resistance and hyperglycemia might be more readily understood if viewed in the context of underlying abnormalities of lipid metabolism.