Prion proteins and copper ions. Biological and chemical controversies

作者：Henryk Kozłowski, Marek Łuczkowski, Maurizio Remelli · 发表于：Dalton Transactions · 年份：2010 · DOI：10.1039/c001267j · 被引用次数：67 · 研究领域：Prion Diseases and Protein Misfolding、Trace Elements in Health、Neurological diseases and metabolism

The Prion protein (PrP(c)) involvement in some neurodegenerative diseases is well assessed although its "normal" biological role is not completely understood. It is known that PrP(C) can bind Cu(II) ions with high specificity but the order of magnitude of the corresponding affinity constant(s) is still highly debated. This perspective is an attempt to collect the current knowledge on these topics and to build up a bridge between the biological and the chemical points of view.