In vitro evaluation of CP-62,993, erythromycin, clindamycin, and tetracycline against Chlamydia trachomatis

作者：Martin Austin Walsh, Elizabeth W. Kappus, Thomas C. Quinn · 发表于：Antimicrobial Agents and Chemotherapy · 年份：1987 · DOI：10.1128/aac.31.5.811 · 被引用次数：40 · 研究领域：Reproductive tract infections research、Cervical Cancer and HPV Research、Veterinary medicine and infectious diseases

The antimicrobial activity of CP-62,993 against four Chlamydia trachomatis isolates was compared with those of erythromycin, clindamycin, and tetracycline. The MIC of CP-62,993 was 0.26 to 1.02 micrograms/ml for 100% inclusion inhibition and 0.031 to 0.063 microgram/ml for 50% inclusion inhibition. With pharmacokinetic and antimicrobial studies demonstrating prolonged half-life and in vitro effectiveness, CP-62,993 may make possible a single, short-course treatment regimen for C. trachomatis infection.