Liver Transplantation with Use of Cyclosporin a and Prednisone

作者：Thomas E. Starzl, Göran Bo Gustaf Klintmalm, Kendrick A. Porter, Shunzaburo Iwatsuki, G Schröter · 发表于：New England Journal of Medicine · 年份：1981 · DOI：10.1056/nejm198107303050507 · 被引用次数：496 · 研究领域：Renal Transplantation Outcomes and Treatments、Organ Transplantation Techniques and Outcomes、Liver Disease and Transplantation

THE difficulties in consistently prolonging survival after orthotopic liver transplantation have been documented by us1 and by Calne.2 In this report we describe a new trial of orthotopic liver transplantation in 14 patients who were scheduled to be treated with cyclosporin A and prednisone. Two patients died during the operation. Ten (83 per cent) of the 12 patients who survived surgery and received the drugs are living after eight to 14 1/2 months; another lived for a year, before dying of a recurrence of cholangiocarcinoma.Although longer follow-up periods and more case studies will be required to establish the safety . . .