The Recirculation of T and B Lymphocytes in the Athymic, Nude Rat

作者：S. POSSUM, M. E. Smith, W. L. Ford · 发表于：Scandinavian Journal of Immunology · 年份：1983 · DOI：10.1111/j.1365-3083.1983.tb00823.x · 被引用次数：45 · 研究领域：Immune Response and Inflammation、Immunotherapy and Immune Responses、T-cell and B-cell Immunology

The recirculation of lymphocytes through the tissues and their return to the blood were compared in nude and euthymic rats. Three approaches were used: the organ distribution of 15Cr-labelled lymphocytes from nude or euthymic donors at 24 h after injection; the compartmental distribution of B and T lymphocytes as assessed by autoradiography of the spleen, lymph nodes, and Peyer's patches; and the tempo of recirculation from blood to thoracic duct lymph as estimated by counting timed fractions of lymph from a recipient of labelled lymphocytes. The following conclusions were drawn: (1) The distribution of lymphocytes between organs and within organs is very similar in nude and euthymic recipients. In particular, B lymphocytes proceed normally to the follicular areas in the absence of T cells. (2) The recirculation from blood to lymph is delayed in nude rats. (3) For equal numbers of B and T cells injected intravenously about half as many B cells as T cells enter mesenteric and cervical lymph nodes, but approximately equal numbers of B and T cells enter the spleen and Peyer's patches.