Childhood bullous pemphigoid treated by i.v. immunoglobulin

作者：Ting Xiao, Bo Li, Yakun Wang, Chundi He, Hong‐Duo Chen · 发表于：The Journal of Dermatology · 年份：2007 · DOI：10.1111/j.1346-8138.2007.00348.x · 被引用次数：28 · 研究领域：Autoimmune Bullous Skin Diseases、Urticaria and Related Conditions、Coagulation, Bradykinin, Polyphosphates, and Angioedema

Bullous pemphigoid is an acquired autoimmune subepidermal blistering disorder mostly seen in the elderly. Childhood bullous pemphigoid is very rare. For the first time we report a case of childhood bullous pemphigoid associated with infantile eczema. Two weeks after a routine vaccination, a 3.5-month-old boy with infantile eczema developed a generalized blistering disorder. Histopathology revealed a subepidermal blister. Direct immunofluorescence showed linear depositions of C3 along the basement membrane zone. Indirect immunofluorescence studies demonstrated the presence of circulating immunoglobulin G antibodies directed against the epidermal side of salt-split skin. Enzyme-linked immunosorbent assay demonstrated serum level of anti-BP180 antibody elevated. The patient was successfully treated by high-dose i.v. immunoglobulin.