Nuclear Localization and DNA Binding Properties of a Protein Expressed by Human c- myc Oncogene

作者：Håkan Persson, Philip Leder · 发表于：Science · 年份：1984 · DOI：10.1126/science.6463648 · 被引用次数：285 · 研究领域：DNA Repair Mechanisms、Metal complexes synthesis and properties、DNA and Nucleic Acid Chemistry

Antisera to the human cellular myc oncogene product were used to identify a human c-myc specific protein with a molecular weight of 65,000. Subcellular fractionation showed that the human c-myc protein is predominantly found in the cell nucleus. The p65Kc-myc protein binds to double- and single-stranded DNA as measured by a DNA affinity chromatography assay.