Different airway responsiveness profiles in atopic asthma, nonatopic asthma, and Sjögren's syndrome

作者：Dóra Lúðvíksdóttir, Christer Janson, Eythor Hreinn Bjornsson, Gunnemar Stålenheim, G Boman, BHR Study Group, Hans Hedenström, Per Venge, Björn Guðbjörnsson, Sigrídur Th. Valtýsdóttir · 发表于：Allergy · 年份：2000 · DOI：10.1034/j.1398-9995.2000.00252.x · 被引用次数：67 · 研究领域：Asthma and respiratory diseases、Chronic Obstructive Pulmonary Disease (COPD) Research、Respiratory and Cough-Related Research

BACKGROUND: Different mechanisms may underlie bronchial hyperresponsiveness (BHR) in different diseases. The aim of this study was to investigate the bronchial responsiveness profile produced by three different challenge tests, methacholine, a direct stimulus, and two indirect stimuli, adenosine 5'-monophosphate (AMP) and cold air, in subjects with asthma and patients with Sjögren's syndrome. METHODS: The study population comprised 40 adult patients with asthma, 18 subjects with Sjögren's syndrome, and 20 controls. Blood samples were collected before each challenge for measurements of serum eosinophil peroxidase (S-EPO) and eosinophil cationic protein (S-ECP). The investigated subjects recorded peak expiratory flow and kept a symptom diary. RESULTS: Atopic subjects with asthma were significantly more hyperresponsive to AMP than nonatopic subjects with asthma (P=0.01) and subjects with Sjögren's syndrome (P=0.02). No difference was seen between atopic and nonatopic subjects with asthma in the case of challenges with methacholine or cold air. In atopic subjects with asthma, a significant correlation was found between challenges with methacholine and AMP (r=0.91, P=0.0001) and methacholine and cold air (r=0.83, P=0.004), but, in nonatopic subjects with asthma, no significant correlation was seen between methacholine and AMP or cold air challenges. In atopic subjects with asthma, the dose-response slope for AMP was correlated to S-EPO (r= -0.56; P = 0.01) and S-ECP (r= -0.51, P =...