Immunochemical studies for the presence of P-450 HFLa, a form of cytochrome P-450 in human fetal livers in human hepatocellular carcinoma cells.

作者：Mitsukazu Kitada, Kazuo Tsukidate, Jun Takeuchi, Masaki Taneda, Masayuki Komori, Hiroaki Ohi, K. Itahashi, Tetsuya Kamataki · 发表于：Journal of Pharmacobio-Dynamics · 年份：1989 · DOI：10.1248/bpb1978.12.341 · 被引用次数：8 · 研究领域：Pharmacogenetics and Drug Metabolism、Drug Transport and Resistance Mechanisms、Metabolism and Genetic Disorders

Immunohistochemical localization of P-450 HFLa, a form of cytochrome P-450 in human fetal livers was investigated in human hepatocellular carcinoma. The cytoplasm of carcinoma cells positively reacted with anti-P-450 HFLa antibodies. It was found that the carcinoma cells showing a pseudoglandular pattern or poorly differentiated appearance exhibited a weaker reactivity with anti-P-450 HFLa antibodies than did relatively differentiated carcinoma cells. In the case of hepatoblastoma, the polygonal or round-shaped tumor cells which differentiated into epithelial structure exhibited a positive reaction with anti-P-450 HFLa antibodies, whereas the spindle-shaped tumor cells which showed a sarcomatous appearance did not react with the antibodies.