Infusional 5-fluorouracil and x-ray therapy for non-resectable esophageal cancer

作者：J.E. Byfield, Rita Maria Elisa Barone, J. Mendelsohn, Sallie S. Frankel, Llura Quinol, Thomas Robert Sharp, Stephen L. Seagren · 发表于：Cancer · 年份：1980 · DOI：10.1002/1097-0142(19800215)45:4<703::aid-cncr2820450415>3.0.co;2-q · 被引用次数：127 · 研究领域：Esophageal Cancer Research and Treatment、Lung Cancer Diagnosis and Treatment、Lung Cancer Treatments and Mutations

Six patients with unresectable carcinoma of the esophagus received a combined course of external radiation therapy (1000 rads in four fractions in four days commencing on day 2) combined with constant infusional 5-fluorouracil (20 mg/kg every 24 hours for five days beginning on day 1). This program was repeated every other week to give a total x-ray dose of 6000 rads. This regimen has been well-tolerated by the majority of the patients and resulted in a complete response rate within the x-ray treatment field of 83% (5/6). All patients who showed a demonstrable systemic response to 5-fluorouracil reached complete response. The median survival has not yet been reached at six months with post-treatment survivors alive and without disease (four patients) at one, six, nine, and 22 months. Our previous median survival by x-ray therapy alone was 4 1/2 months. Toxicity consists primarily of hematologic suppression at a subclinical level. Although the length of therapy is substantial (11 weeks), the program appears tolerable and is capable of inducing long-term remissions. The program is currently being studied for dose escalation because neither local nor systemic side effects of a dose-limiting nature have been observed at 20 mg/kg 5-FU.