International consensus for neuroblastoma molecular diagnostics: report from the International Neuroblastoma Risk Group (INRG) Biology Committee

作者：Peter F. Ambros, I.M. Ambros, G M Brodeur, Michelle Haber, Javed Iqbal Khan, Akira Nakagawara, Gudrun Schleiermacher, Frank Speleman, Raphaël Eftimie Spitz, W. B. London, Susan Lerner Cohn, ADJ Pearson, J.M. Maris · 发表于：British Journal of Cancer · 年份：2009 · DOI：10.1038/sj.bjc.6605014 · 被引用次数：409 · 研究领域：Neuroblastoma Research and Treatments、Lung Cancer Research Studies、Cancer, Hypoxia, and Metabolism

Neuroblastoma serves as a paradigm for utilising tumour genomic data for determining patient prognosis and treatment allocation. However, before the establishment of the International Neuroblastoma Risk Group (INRG) Task Force in 2004, international consensus on markers, methodology, and data interpretation did not exist, compromising the reliability of decisive genetic markers and inhibiting translational research efforts. The objectives of the INRG Biology Committee were to identify highly prognostic genetic aberrations to be included in the new INRG risk classification schema and to develop precise definitions, decisive biomarkers, and technique standardisation. The review of the INRG database (n=8800 patients) by the INRG Task Force finally enabled the identification of the most significant neuroblastoma biomarkers. In addition, the Biology Committee compared the standard operating procedures of different cooperative groups to arrive at international consensus for methodology, nomenclature, and future directions. Consensus was reached to include MYCN status, 11q23 allelic status, and ploidy in the INRG classification system on the basis of an evidence-based review of the INRG database. Standardised operating procedures for analysing these genetic factors were adopted, and criteria for proper nomenclature were developed. Neuroblastoma treatment planning is highly dependant on tumour cell genomic features, and it is likely that a comprehensive panel of DNA-based biomarkers ...