Observations on the Regulatory Mechanisms of Aldosterone Secretion in Man

作者：John C. Beck · 发表于：Archives of Internal Medicine · 年份：1955 · DOI：10.1001/archinte.1955.00250150037003 · 被引用次数：43 · 研究领域：Hormonal Regulation and Hypertension、Adrenal Hormones and Disorders、Electrolyte and hormonal disorders

The regulatory mechanisms governing aldosterone secretion in man are as yet obscure. Axelrad and Leutscher1have shown that a fivefold increase in urinary aldosterone occurs in man when the dietary sodium is restricted. Laragh and Stoerk2have suggested that serum potassium is a powerful direct or indirect stimulus to aldosterone secretion and that increases in urinary aldosterone on dietary sodium restriction are mediated by an alteration in serum potassium or Na/K ratio. Although corticotropin does not appear to affect either the excretion * or the blood levels of aldosterone in normal persons,4Gordon and co-workers5have found an increase in the output of this sodiumretaining hormone in a patient with rheumatoid arthritis following the intravenous administration of corticotropin. Leutscher and Axelrad6have observed essentially normal levels of urinary aldosterone in patients with panhypopituitarism. It has been sug- gested by Peters7that the mineralocorticoid output of