Transactivation by AP-1 Is a Molecular Target of T Cell Clonal Anergy

作者：Sang‐Mo Kang, Bart Beverly, Annie-Chen Tran, Kurt Brorson, Ronald H. Schwartz, Michael J. Lenardot · 发表于：Science · 年份：1992 · DOI：10.1126/science.257.5073.1134 · 被引用次数：319 · 研究领域：NF-κB Signaling Pathways、Toxin Mechanisms and Immunotoxins、Immune Cell Function and Interaction

Anergy is a mechanism of T lymphocyte tolerance induced by antigen receptor stimulation in the absence of co-stimulation. Anergic T cells were shown to have a defect in antigen-induced transcription of the interleukin-2 gene. Analysis of the promoter indicated that the transcription factor AP-1 and its corresponding cis element were specifically down-regulated. Exposure of anergic T cells to interleukin-2 restored both antigen responsiveness and activity of the AP-1 element.