Pharmacogenomics and Herb-Drug Interactions: Merge of Future and Tradition

作者：Mou-Ze Liu, Yueli Zhang, Meizi Zeng, Fazhong He, Zhiying Luo, Jian‐Quan Luo, Jiagen Wen, Xiaoping Chen, Hong‐Hao Zhou, Wei Zhang · 发表于：Evidence-based Complementary and Alternative Medicine · 年份：2015 · DOI：10.1155/2015/321091 · 被引用次数：50 · 研究领域：Complementary and Alternative Medicine Studies、Pharmacogenetics and Drug Metabolism、Herbal Medicine Research Studies

The worldwide using of herb products and the increasing potential herb-drug interaction issue has raised enthusiasm on discovering the underlying mechanisms. Previous review indicated that the interactions may be mediated by metabolism enzymes and transporters in pharmacokinetic pathways. On the other hand, an increasing number of studies found that genetic variations showed some influence on herb-drug interaction effects whereas these genetic factors did not draw much attention in history. We highlight that pharmacogenomics may involve the pharmacokinetic or pharmacodynamic pathways to affect herb-drug interaction. We are here to make an updated review focused on some common herb-drug interactions in association with genetic variations, with the aim to help safe use of herbal medicines in different individuals in the clinic.