Polypeptide with Broad Biological Activity: Isolation from Small Intestine

作者：Sami I. Said, Viktor Mutt · 发表于：Science · 年份：1970 · DOI：10.1126/science.169.3951.1217 · 被引用次数：1601 · 研究领域：Coagulation, Bradykinin, Polyphosphates, and Angioedema、Microbial Metabolites in Food Biotechnology、Enzyme function and inhibition

A polypeptide, which has potent and diverse biological action-including systemic vasodilation, hypotension, increased cardiac output, respiratory stimulation, and hyperglycemia-was isolated from the small intestine of the hog. The peptide has 28 amino acid residues and is chemically distinct from the kinins, "substance P," glucagon, and secretin.