Toxinotype VClostridium difficilein Humans and Food Animals

作者：Michael A. Jhung, Angela D. Thompson, George Killgore, Walter E. Zukowski, Glenn Songer, Michael Warny, Stuart Johnson, Dale N. Gerding, L. Clifford McDonald, Brandi M. Limbago · 发表于：Emerging infectious diseases · 年份：2008 · DOI：10.3201/eid1407.071641 · 被引用次数：215 · 研究领域：Clostridium difficile and Clostridium perfringens research、Viral gastroenteritis research and epidemiology

Clostridium difficile is a recognized pathogen in neonatal pigs and may contribute to enteritis in calves. Toxinotype V strains have been rare causes of human C. difficile-associated disease (CDAD). We examined toxinotype V in human disease, the genetic relationship of animal and human toxinotype V strains, and in vitro toxin production of these strains. From 2001 through 2006, 8 (1.3%) of 620 patient isolates were identified as toxinotype V; before 2001, 7 (<0.02%) of approximately 6,000 isolates were identified as toxinotype V. Six (46.2%) of 13 case-patients for whom information was available had community-associated CDAD. Molecular characterization showed a high degree of similarity between human and animal toxinotype V isolates; all contained a 39-bp tcdC deletion and most produced binary toxin. Further study is needed to understand the epidemiology of CDAD caused by toxinotype V C. difficile, including the potential of foodborne transmission to humans.