Degradation of type IX collagen by matrix metalloproteinase 3 (stromelysin) from human rheumatoid synovial cells

作者：Yasunori Okada, Hiroshi Konomi, Toshikazu Yada, Koji Kimata, Hideaki Nagase · 发表于：FEBS Letters · 年份：1989 · DOI：10.1016/0014-5793(89)80586-1 · 被引用次数：98 · 研究领域：Protease and Inhibitor Mechanisms、Osteoarthritis Treatment and Mechanisms、Cell Adhesion Molecules Research

The degradation of type IX collagen, a minor collagen in cartilage, was examined by treatment with three different types of matrix metalloproteinases (MMPs) purified from the culture medium of rheumatoid synovial cells. Neither MMP-1 (collagenase) nor MMP-2 (so-called 'gelatinase') could digest type IX collagen, but MMP-3 (stromelysin) readily degraded it into smaller fragments. This suggests that MMP-3 may be responsible for the pathological degradation and/or normal turnover of type IX collagen.