Prediction value of model for end‐stage liver disease scoring system on prognosis in patients with acute‐on‐chronic hepatitis B liver failure after plasma exchange and lamivudine treatment

作者：Jian‐Wu Yu, Lijie Sun, Yonghua Zhao, Shu Li · 发表于：Journal of Gastroenterology and Hepatology · 年份：2008 · DOI：10.1111/j.1440-1746.2008.05484.x · 被引用次数：58 · 研究领域：Liver Disease and Transplantation、Hepatitis B Virus Studies、Drug-Induced Hepatotoxicity and Protection

BACKGROUND AND AIM: We used the model for end-stage liver disease (MELD) scoring system to predict the 3-month prognosis of patients with acute-on-chronic liver failure (ACLF) after plasma exchange (PE) and lamivudine treatment, and studied the predictive factors on the prognosis of patients. METHODS: A total of 280 patients treated with lamivudine were randomly divided into PE and control groups. The relationship between mortality and influential factors of patients was studied by univariate and multivariate analysis. RESULTS: The mortality (49.4%) of patients in the PE group with a MELD score from 30 to 40 was lower than that (86.1%) of the control group (chi(2) = 24.546, P < 0.01). The total bilirubin (TBIL) rebound rate of the dead group was significantly higher than that of the survival group (P < 0.01). Univariate analysis showed that mortality was significantly related to age (P = 0.003), treatment method (P = 0.000), TBIL (P = 0.010), MELD score (P = 0.001), international normalised ratio (P = 0.014), pretreatment HBV-DNA load (P = 0.000), decline of hepatitis B virus (HBV)-DNA load during therapy (P = 0.013), encephalopathy (P = 0.019), and hepatorenal syndrome (P = 0.026). In multivariate analysis, MELD scores of 30-40, treatment method (P = 0.003), pretreatment HBV-DNA load (P = 0.009), decline of HBV-DNA load during therapy (P = 0.016), and encephalopathy (P = 0.015) were independent predictors of mortality; for MELD scores above 40, only the MELD score (P = 0.012...