The Stimulation of Uterine Blood Flow by Various Estrogens1

作者：Robert R. Resnik, Allen P. Killam, Frederick C. Battaglia, Edgar L. Makowski, Giacomo Meschia · 发表于：Endocrinology · 年份：1974 · DOI：10.1210/endo-94-4-1192 · 被引用次数：153 · 研究领域：Menopause: Health Impacts and Treatments、Estrogen and related hormone effects、Reproductive System and Pregnancy

The response of the uterine vascular bed to various estrogens was investigated in nonpregnant, oophorectomized sheep utilizing electromagnetic flow probes chronically implanted around the uterine arteries. One M.g estradiol-β injected directly into the uterine artery produces a maximum flow response, approximately ten times baseline levels, which is reproducible on a daily basis for periods greater than 30 days. A family of dose response curves demonstrated the following potency for increasing uterine blood flow to 50% of maximum: estradiol-β > estriol > diethylstilbestrol > estradiol-17α > estrone > ent-estradiol- 17β. (Endocrinology94: 1192, 1974)