The structure of the presenilin 1 (S182) gene and identification of six novel mutations in early onset AD families

作者：Robert F. Clark, Melanie L. Hutton, M. Fuldner, Susanne Froelich, Eric H. Karran, Chris J. Talbot, Richard Crook, C Lendon, Guy Prihar, C. He, Kevin Korenblat, Alonso Martínez, Michelle A. Wragg, Frances Busfield, María Isabel Behrens, A. Myers, Joanne B. Norton, John C. Morris, Nitin D. Mehta, Christopher E. Pearson, S. J. Lincoln, Matt C. Baker, Karen Duff, Cindy Zehr, Jordi Pérez‐Tur, Henry Houlden, A. Ruiz, J. Ossa, Francisco Javier Lopera, Mauricio Arcos‐Burgos, Lorena Madrigal, John Collinge, Christopher M. Humphreys, Alan Ashworth, S. Sarner, Nick C. Fox, Richard J. Harvey, Angus M Kennedy, Penelope Roques, Robin T. Cline, C.A. Philips, J. Craig Venter, Lotta Forsell, Karin Axelman, Lena Lilius, Janet A. Johnston, Richard F. Cowburn, Matti H. Viitanen, Bengt G. Winblad, K S Kosik, Matti Haltia, Minna Pöyhönen, Dennis W. Dickson, David Mann, David Neary, Julie S. Snowden, Peter L. Lantos, Lars Lannfelt, Martin N. Rossor, Gareth W. Roberts, Mark D. Adams, John Hardy, Alison Goate · 发表于：Nature Genetics · 年份：1995 · DOI：10.1038/ng1095-219 · 被引用次数：478 · 研究领域：Alzheimer's disease research and treatments、Cholinesterase and Neurodegenerative Diseases、Computational Drug Discovery Methods