Cancer Cell Cycles

作者：Charles J. Sherr · 发表于：Science · 年份：1996 · DOI：10.1126/science.274.5293.1672 · 被引用次数：5407 · 研究领域：Cancer-related Molecular Pathways、Epigenetics and DNA Methylation、Cancer Research and Treatments

Uncontrolled cell proliferation is the hallmark of cancer, and tumor cells have typically acquired damage to genes that directly regulate their cell cycles. Genetic alterations affecting p16(INK4a) and cyclin D1, proteins that govern phosphorylation of the retinoblastoma protein (RB) and control exit from the G1 phase of the cell cycle, are so frequent in human cancers that inactivation of this pathway may well be necessary for tumor development. Like the tumor suppressor protein p53, components of this "RB pathway," although not essential for the cell cycle per se, may participate in checkpoint functions that regulate homeostatic tissue renewal throughout life.