Definitions and outcome measures for mucous membrane pemphigoid: Recommendations of an international panel of experts

作者：Dedee Frances Murrell, Branka Marinović, Frédéric A. Caux, Cathérine Prost, Razzaque Ahmed, Katarzyna Woźniak, Masayuki Amagai, Johann Wolfgang Bauer, Stefan Beissert, Luca Borradori, Donna Aline Culton, Janet A. Fairley, David P. Fivenson, Marcel F. Jonkman, M. Peter Marinkovich, David T. Woodley, John J. Zone, Valéria Aoki, Philippe M. Bernard, Leena Bruckner‐Tuderman, Giuseppe Cianchini, Vanessa A. Venning, Luis Alfonso Díaz‐Martínez, Rüdiger Eming, Sergei A. Grando, Russell P. Hall, Takashi Hashimoto, Josep E. Herrero‐González, Michael Hertl, P. Joly, Sarolta Kárpáti, Jaehwan Kim, Soo‐Chan Kim, Neil J. Korman, Cezary Kowaléwski, Sang Eun Lee, David Ari Rubenstein, Eli Sprecher, Kim B. Yancey, Giovanna Zambruno, Detlef Zillikens, Serge Doan, Benjamin S. Daniel, Victoria P. Werth · 发表于：Journal of the American Academy of Dermatology · 年份：2014 · DOI：10.1016/j.jaad.2014.08.024 · 被引用次数：158 · 研究领域：Autoimmune Bullous Skin Diseases、Coagulation, Bradykinin, Polyphosphates, and Angioedema、Urticaria and Related Conditions

Mucous membrane pemphigoid encompasses a group of autoimmune bullous diseases with a similar phenotype characterized by subepithelial blisters, erosions, and scarring of mucous membranes, skin, or both. Although knowledge about autoimmune bullous disease is increasing, there is often a lack of clear definitions of disease, outcome measures, and therapeutic end points. With clearer definitions and outcome measures, it is possible to directly compare the results and data from various studies using meta-analyses. This consensus statement provides accurate and reproducible definitions for disease extent, activity, outcome measures, end points, and therapeutic response for mucous membrane pemphigoid and proposes a disease extent score, the Mucous Membrane Pemphigoid Disease Area Index.