A possible novel interaction between the 3′‐end of 18 S ribosomal RNA and the 5'‐leader sequence of many eukaryotic messenger RNAs

作者：David R. Sargan, Stephen P. Gregory, Peter H.W. Butterworth · 发表于：FEBS Letters · 年份：1982 · DOI：10.1016/0014-5793(82)81026-0 · 被引用次数：69 · 研究领域：RNA and protein synthesis mechanisms、RNA Research and Splicing、Monoclonal and Polyclonal Antibodies Research

A novel interaction between the 5'-untranslated region of eukaryotic messenger RNAs and non-contiguous sequences in the 18 S ribosomal RNA is proposed. The small ribosomal RNA contains, at its 3'-terminus, a heavily conserved hairpin structure. It is suggested that mRNA 5'-leader sequence stabilises this structure by interacting with other conserved nucleotides which flank it. Sequences closely related to the required sequence (A-U-C-C-A-C-C) occur quite commonly in eukaryotic mRNAs and are often found immediately upstream from the AUG-codon. This interaction may have a role in the events which lead up to the initiation of protein synthesis.