Codon reiteration and the evolution of proteins.

作者：H Green, Ningning Wang · 发表于：Proceedings of the National Academy of Sciences · 年份：1994 · DOI：10.1073/pnas.91.10.4298 · 被引用次数：92 · 研究领域：RNA and protein synthesis mechanisms、Genomics and Phylogenetic Studies、Machine Learning in Bioinformatics

Sequence data banks have been searched for proteins possessing uninterrupted reiterations of any amino acid. Hydrophilic amino acids, and particularly glutamine, account for a large proportion of the longer reiterants. In the genes for these proteins, the most common reiterants are those that contain poly(CAG), even out-of-frame or, to a lesser degree, those that contain repeated doublets of CA, AG, or GC. The preferential generation of such reiterants requires that DNA strand-specific signals predispose to reiteration and thus to the extension of coding regions.