Dose response studies using desferrioxamine and orally active chelators in a mouse model

作者：George J. Kontoghiorghes · 发表于：Scandinavian Journal of Haematology · 年份：1986 · DOI：10.1111/j.1600-0609.1986.tb01773.x · 被引用次数：40 · 研究领域：Hemoglobinopathies and Related Disorders、Drug Transport and Resistance Mechanisms、Pharmacological Effects and Toxicity Studies

59Fe excretion studies in response to different doses (4-9 mg) of three N-substituted 3-hydroxypyrid-4-one chelators, (1,2-dimethyl-3-hydroxypyrid-4-one, 1-ethyl-2-methyl-3-hydroxypyrid-4-one, 1-propyl-2-methyl-3-hydroxypyrid-4-one), and desferrioxamine in iron overloaded 59Fe lactoferrin labelled mice (40 +/- 4 g) have shown that the former chelators, when administered intraperitoneally and intragastrically, caused comparable 59Fe excretions to intraperitoneal desferrioxamine of equivalent doses. No apparent ill effects were observed when doses of 300 mg/kg were administered for 24 d.