Neoadjuvant therapy for oesophagogastric cancer

作者：Florian Lordick, Hubert J. Stein, Christian Peschel, Joerg R. Siewert · 发表于：British journal of surgery · 年份：2004 · DOI：10.1002/bjs.4575 · 被引用次数：95 · 研究领域：Esophageal Cancer Research and Treatment、Gastric Cancer Management and Outcomes、Inflammatory Biomarkers in Disease Prognosis

BACKGROUND: The prognosis after surgery for oesophagogastric cancer remains poor. METHODS: This review clarifies current indications for neoadjuvant therapy for oesophageal and gastric cancer. A systematic literature research and evaluation of data from international cancer meetings were carried out. RESULTS: Recently published results of large randomized phase III trials underscore the potential value of neoadjuvant treatment for oesophagogastric cancer. However, it remains uncertain which subgroups of patients should routinely undergo preoperative therapy. Metabolic response evaluation during neoadjuvant treatment is a promising tool for the selection of responding patients. CONCLUSION: Neoadjuvant chemotherapy is a valid option for locally advanced oesophageal and gastric cancer. In the future, more effective and better tolerated treatment strategies, tailored to the specific tumour characteristics of each individual, should be possible.