The cytomatrix: a short history of its study.

作者：Keith R. Porter · 发表于：The Journal of Cell Biology · 年份：1984 · DOI：10.1083/jcb.99.1.3s · 被引用次数：170 · 研究领域：Cell Image Analysis Techniques

As early as 1820 and for several decades thereafter the early observers of the cytomatrix worked mostly with the light microscope and very simple equipment. It was not uncommon for the investigator simply to crush a cell between two slides and watch the results. The sole motivation for these studies, as far as I can judge, was the satisfaction of curiosity, for there were no grants. Such observations are valuable to us today, especially those accompanied by imaginative interpretations. Studies on the cytomatrix fall roughly into three periods, the early, middle, and recent. The early period, which was mostly descriptive, was the longest and filled the yearsbetween 1820 and 1910. It was a time when light microscopes were greatly improved, when chemical fixatives were discovered, when microtomes and staining procedures were introduced, and when the community of biologists became aware of cells