Marginal zone macrophages in the mouse spleen identified by a monoclonal antibody. Anatomical correlation with a B cell subpopulation.

作者：Esmée van Vliet, Marleen Melis, Willem van Ewijk · 发表于：Journal of Histochemistry & Cytochemistry · 年份：1985 · DOI：10.1177/33.1.3880783 · 被引用次数：97 · 研究领域：Diabetes and associated disorders、Immune responses and vaccinations、Pancreatitis Pathology and Treatment

The reactivity of a monoclonal antibody, ER-TR9, that demonstrates heterogeneity among mononuclear phagocytes is described. In the spleen, ER-TR9 exclusively reacts with a population of macrophages located in the marginal zone. ER-TR9 does not react with macrophage antigen 1-positive red pulp macrophages or any other types of splenic stromal cells. ER-TR9+ ve cells localize in anatomical proximity of a subpopulation of B cells, i.e., B cells that are immunoglobulin M positive and weakly positive to negative for immunoglobulin D. The possible significance of this particular interaction between both cell types during the immune response is discussed.