Dairy Consumption, Obesity, and the Insulin Resistance Syndrome in Young Adults

作者：Mark A. Pereira, David R. Jacobs, Linda Van Horn, Martha L. Slattery, Alex I. Kartashov, David S. Ludwig · 发表于：JAMA · 年份：2002 · DOI：10.1001/jama.287.16.2081 · 被引用次数：1092 · 研究领域：Nutritional Studies and Diet、Diabetes, Cardiovascular Risks, and Lipoproteins、Adipokines, Inflammation, and Metabolic Diseases

CONTEXT: Components of the insulin resistance syndrome (IRS), including obesity, glucose intolerance, hypertension, and dyslipidemia, are major risk factors for type 2 diabetes and heart disease. Although diet has been postulated to influence IRS, the independent effects of dairy consumption on development of this syndrome have not been investigated. OBJECTIVE: To examine associations between dairy intake and incidence of IRS, adjusting for confounding lifestyle and dietary factors. DESIGN: The Coronary Artery Risk Development in Young Adults (CARDIA) study, a population-based prospective study. SETTING AND PARTICIPANTS: General community sample from 4 US metropolitan areas of 3157 black and white adults aged 18 to 30 years who were followed up from 1985-1986 to 1995-1996. MAIN OUTCOME MEASURE: Ten-year cumulative incidence of IRS and its association with dairy consumption, measured by diet history interview. RESULTS: Dairy consumption was inversely associated with the incidence of all IRS components among individuals who were overweight (body mass index > or =25 kg/m(2)) at baseline but not among leaner individuals (body mass index < 25 kg/m(2)). The adjusted odds of developing IRS (2 or more components) were 72% lower (odds ratio, 0.28; 95% confidence interval, 0.14-0.58) among overweight individuals in the highest (> or =35 times per week, 24/102 individuals) compared with the lowest (<10 times per week, 85/190 individuals) category of dairy consumption. Each daily occasio...