Cobalt‐Catalyzed, Aminoquinoline‐Directed C(sp 2 )H Bond Alkenylation by Alkynes

作者：Liene Grigorjeva, Olafs Daugulis · 发表于：Angewandte Chemie International Edition · 年份：2014 · DOI：10.1002/anie.201404579 · 被引用次数：509 · 研究领域：Catalytic C–H Functionalization Methods、Synthesis and Catalytic Reactions、Sulfur-Based Synthesis Techniques

A method for cobalt-catalyzed, aminoquinoline- and picolinamide-directed C(sp(2))-H bond alkenylation by alkynes was developed. The method shows excellent functional-group tolerance and both internal and terminal alkynes are competent substrates for the coupling. The reaction employs a Co(OAc)2⋅4 H2O catalyst, Mn(OAc)2 co-catalyst, and oxygen (from air) as a terminal oxidant.