In vitro activity of a new macrolide, A-56268, compared with that of roxithromycin, erythromycin, and clindamycin

作者：A L Barry, C Thornsberry, Ronald N. Jones · 发表于：Antimicrobial Agents and Chemotherapy · 年份：1987 · DOI：10.1128/aac.31.2.343 · 被引用次数：45 · 研究领域：Antimicrobial Resistance in Staphylococcus、Antibiotic Resistance in Bacteria、Pneumonia and Respiratory Infections

A new macrolide (A-56268) was found to be approximately twice as active as erythromycin and four to eight times more active than roxithromycin. All three macrolides were similar in their potency against anaerobes. Human plasma enhanced the antistaphylococcal activity of A-56268 and erythromycin but reduced the activities of roxithromycin and clindamycin.