The Insulin-Like Growth Factor System and Its Pleiotropic Functions in Brain

作者：Vincenzo C. Russo, Peter David Gluckman, Eva L. Feldman, George Arthur Werther · 发表于：Endocrine Reviews · 年份：2005 · DOI：10.1210/er.2004-0024 · 被引用次数：495 · 研究领域：Growth Hormone and Insulin-like Growth Factors、Pancreatic function and diabetes、Diet and metabolism studies

In recent years, much interest has been devoted to defining the role of the IGF system in the nervous system. The ubiquitous IGFs, their cell membrane receptors, and their carrier binding proteins, the IGFBPs, are expressed early in the development of the nervous system and are therefore considered to play a key role in these processes. In vitro studies have demonstrated that the IGF system promotes differentiation and proliferation and sustains survival, preventing apoptosis of neuronal and brain derived cells. Furthermore, studies of transgenic mice overexpressing components of the IGF system or mice with disruptions of the same genes have clearly shown that the IGF system plays a key role in vivo.