Pharmacogenomics: Translating Functional Genomics into Rational Therapeutics

作者：William Edward Evans, Mary V. Relling · 发表于：Science · 年份：1999 · DOI：10.1126/science.286.5439.487 · 被引用次数：2500 · 研究领域：Pharmacogenetics and Drug Metabolism、Computational Drug Discovery Methods、Metabolomics and Mass Spectrometry Studies

Genetic polymorphisms in drug-metabolizing enzymes, transporters, receptors, and other drug targets have been linked to interindividual differences in the efficacy and toxicity of many medications. Pharmacogenomic studies are rapidly elucidating the inherited nature of these differences in drug disposition and effects, thereby enhancing drug discovery and providing a stronger scientific basis for optimizing drug therapy on the basis of each patient's genetic constitution.