Flavonoids as Inhibitors of Lens Aldose Reductase

作者：S.D. Varma, Ikuo Mikuni, J. H. Kinoshita · 发表于：Science · 年份：1975 · DOI：10.1126/science.1145193 · 被引用次数：179 · 研究领域：Aldose Reductase and Taurine、Plant Toxicity and Pharmacological Properties、Biochemical effects in animals

Flavonoids are effective inhibitors of lens aldose reductase. Quercetin, quercitrin, and myricitrin are significantly more potent than the previously known aldose reductase inhibitors. The inhibitory activity is of the noncompetitive type. In addition, quercitrin effectively blocks polyol accumulation in intact rat lenses incubated in medium containing high concentration of sugars.