The Effect of Subclinical Ketosis in Early Lactation on Reproductive Performance of Postpartum Dairy Cows

作者：R.B. Walsh, John S. Walton, D.F. Kelton, S.J. LeBlanc, Ken E. Leslie, T.F. Duffield · 发表于：Journal of Dairy Science · 年份：2007 · DOI：10.3168/jds.2006-560 · 被引用次数：359 · 研究领域：Reproductive Physiology in Livestock、Ruminant Nutrition and Digestive Physiology、Genetic and phenotypic traits in livestock

Data generated from 796 Holstein cows enrolled in a clinical trial to investigate the health effect of a monensin controlled release capsule were analyzed to investigate the association between circulating serum beta-hydroxybutyrate (BHBA) concentration in the peri-parturient period and subsequent reproductive performance. Overall, accounting for both repeated measures within cow and clustering at the herd level, non-pregnant cows after first insemination tended to have increased circulating BHBA concentrations from 3 wk before calving to 9 wk after calving relative to pregnant cows. Including the interaction between the week of sample collection and pregnancy outcome, non-pregnant cows had higher circulating BHBA concentrations in the second week after calving than cows diagnosed pregnant after first artificial insemination. Within individual weeks, cows with circulating BHBA concentrations > or =1,000 micromol/L in the first week postpartum were less likely to be diagnosed pregnant after first insemination. In the second week postpartum, the cows with circulating BHBA concentrations > or =1,400 micromol/L were significantly less likely to be pregnant after first artificial insemination. A dose response relationship was found when a comparison of the probability of pregnancy after first insemination and duration of elevated circulating ketone bodies was investigated. The probability of pregnancy was reduced by 20% in cows diagnosed subclinically ketotic in either the first o...