The Pathogenesis of the Antiphospholipid Syndrome

作者：Bill Giannakopoulos, Steven A. Krilis · 发表于：New England Journal of Medicine · 年份：2013 · DOI：10.1056/nejmra1112830 · 被引用次数：690 · 研究领域：Systemic Lupus Erythematosus Research、Systemic Sclerosis and Related Diseases、Platelet Disorders and Treatments

The antiphospholipid syndrome is a prothrombotic disorder associated with autoantibodies. It is associated with obstetrical complications (mainly spontaneous abortion) as well as venous and arterial thrombotic risks. Insights into disease mechanisms have led to new therapies.