Choline Acetyltransferase Activity in Striatum of Neonatal Rats Increased by Nerve Growth Factor

作者：William Cary Mobley, Julia Lynn Rutkowski, Gihan I Tennekoon, Karen Buchanan, Michael V. Johnston · 发表于：Science · 年份：1985 · DOI：10.1126/science.2861660 · 被引用次数：482 · 研究领域：Neurological Disorders and Treatments、Biochemical effects in animals、Cholinesterase and Neurodegenerative Diseases

Some neurodegenerative disorders may be caused by abnormal synthesis or utilization of trophic molecules required to support neuronal survival. A test of this hypothesis requires that trophic agents specific for the affected neurons be identified. Cholinergic neurons in the corpus striatum of neonatal rats were found to respond to intracerebroventricular administration of nerve growth factor with prominent, dose-dependent, selective increases in choline acetyltransferase activity. Cholinergic neurons in the basal forebrain also respond to nerve growth factor in this way. These actions of nerve growth factor may indicate its involvement in the normal function of forebrain cholinergic neurons as well as in neurodegenerative disorders involving such cells.