Gramene 2013: comparative plant genomics resources

作者：Marcela K. Monaco, Joshua C. Stein, Sushma Naithani, Sharon Wei, Palitha D. Dharmawardhana, Sunita Kumari, Vindhya Amarasinghe, Ken Youens‐Clark, James Thomason, Justin Preece, Shiran Pasternak, Andrew J. Olson, Yinping Jiao, Zhenyuan Lu, Dan M Bolser, Arnaud Kerhornou, Daniel Michael Staines, Brandon Walts, Guanming Wu, Peter D’Eustachio, Robin Haw, David W. Croft, Paul Julian Kersey, Lincoln Stein, Pankaj Jaiswal, Doreen Ware · 发表于：Nucleic Acids Research · 年份：2013 · DOI：10.1093/nar/gkt1110 · 被引用次数：172 · 研究领域：Genomics and Phylogenetic Studies、Genetic Mapping and Diversity in Plants and Animals、Microbial Metabolic Engineering and Bioproduction

Gramene (http://www.gramene.org) is a curated online resource for comparative functional genomics in crops and model plant species, currently hosting 27 fully and 10 partially sequenced reference genomes in its build number 38. Its strength derives from the application of a phylogenetic framework for genome comparison and the use of ontologies to integrate structural and functional annotation data. Whole-genome alignments complemented by phylogenetic gene family trees help infer syntenic and orthologous relationships. Genetic variation data, sequences and genome mappings available for 10 species, including Arabidopsis, rice and maize, help infer putative variant effects on genes and transcripts. The pathways section also hosts 10 species-specific metabolic pathways databases developed in-house or by our collaborators using Pathway Tools software, which facilitates searches for pathway, reaction and metabolite annotations, and allows analyses of user-defined expression datasets. Recently, we released a Plant Reactome portal featuring 133 curated rice pathways. This portal will be expanded for Arabidopsis, maize and other plant species. We continue to provide genetic and QTL maps and marker datasets developed by crop researchers. The project provides a unique community platform to support scientific research in plant genomics including studies in evolution, genetics, plant breeding, molecular biology, biochemistry and systems biology.